| Date | Location | Result | |
| 03/01/22 | Charlotte, NC | Presbyterian 65, Winthrop 60 | Box score |
| 02/26/22 | Boiling Springs, NC | Gardner-Webb 80, Winthrop 51 | Box score |
| 02/23/22 | Buies Creek, NC | Campbell 78, Winthrop 35 | Box score |
| 02/21/22 | Rock Hill, SC | High Point 58, Winthrop 42 | Box score |
| 02/19/22 | Rock Hill, SC | Winthrop 62, Radford 47 | Box score |
| 02/17/22 | Radford, VA | Radford 67, Winthrop 50 | Box score |
| 02/15/22 | North Charleston, SC | Winthrop 56, Charleston So. 43 | Box score |
| 02/12/22 | Rock Hill, SC | Longwood 78, Winthrop 56 | Box score |
| 02/09/22 | Spartanburg, SC | USC Upstate 59, Winthrop 47 | Box score |
| 02/08/22 | Rock Hill, SC | USC Upstate 73, Winthrop 43 | Box score |
| 02/05/22 | High Point, NC | High Point 86, Winthrop 44 | Box score |
| 02/01/22 | Rock Hill, SC | Winthrop 58, Presbyterian 42 | Box score |
| 01/29/22 | Rock Hill, SC | Winthrop 75, UNC Asheville 54 | Box score |
| 01/26/22 | HAMPTON | Hampton University 80, Winthrop 64 | Box score |
| 01/23/22 | Farmville, VA | Longwood 85, Winthrop 58 | Box score |
| 01/22/22 | Greensboro, NC | N.C. A&T 87, Winthrop 64 | Box score |
| 01/19/22 | Rock Hill, SC | Campbell 77, Winthrop 54 | Box score |
| 01/15/22 | Rock Hill, SC | Gardner-Webb 77, Winthrop 51 | Box score |
| 12/29/21 | Rock Hill, SC | Charleston So. 67, Winthrop 54 | Box score |
| 12/19/21 | Charlotte, NC | Charlotte 78, Winthrop 42 | Box score |
| 12/16/21 | Baltimore, MD | Coppin St. 68, Winthrop 43 | Box score |
| 12/12/21 | Rock Hill, SC | Winthrop 62, Claflin 56 | Box score |
| 12/04/21 | Rock Hill, SC | Winthrop 71, Western Caro. 55 | Box score |
| 12/01/21 | Rock Hill, SC | UNCW 55, Winthrop 48 | Box score |
| 11/27/21 | Rock Hill, SC | UNC Pembroke 65, Winthrop 45 | Box score |
| 11/24/21 | Rock Hill, SC | Coker 51, Winthrop 44 | Box score |
| 11/21/21 | Lexington, KY | Kentucky 92, Winthrop 47 | Box score |
| 11/18/21 | Greensboro, NC | UNC Greensboro 69, Winthrop 39 | Box score |
| 11/13/21 | New Rochelle, NY | Iona 67, Winthrop 45 | Box score |
| 11/09/21 | Durham, NC | Duke 95, Winthrop 39 | Box score |