| Date | Location | Result | |
| 03/10/06 | Lynchburg, Va. (Vines Center) | #1-seed Liberty 53, #4-seed Winthrop 45 | Box score |
| 3-7-06 | Winthrop Coliseum | WINTHROP 55, Radford 44 | Box score |
| 3-3-06 | Winthrop Coliseum, Rock Hill, SC | WINTHROP 64, High Point University 60 | Box score |
| 02-27-06 | Kimbel Arena, Conway, S.C. | WINTHROP 54, Coastal Carolina 44 | Box score |
| 2/25/06 | Charleston, S.C. (CSU Fieldhouse) | WINTHROP 58, Charleston Southern 50 | Box score |
| 2-22-06 | Winthrop Coliseum, Rock Hill, SC | Liberty 61, WINTHROP 51 | Box score |
| 2-19-06 | Winthrop Coliseum, Rock Hill, SC | Radford 51, WINTHROP 49 | Box score |
| 02/14/06 | Asheville, N.C./ Justice Center | UNC Asheville 49, WINTHROP 47 | Box score |
| 2-11-06 | Winthrop Coliseum, Rock Hill, SC | Birmingham-Southern 63, WINTHROP 57 | Box score |
| 2-07-06 | Winthrop Coliseum, Rock Hill, SC | COASTAL 63, WINTHROP 51 | Box score |
| 02-04-06 | High Point, N.C.- Millis Athletic Center | High Point University 57, Winthrop University 51 | Box score |
| 1-28-06 | Winthrop Coliseum, Rock Hill, SC | WINTHROP 72, CSUW 43 | Box score |
| 1/23/06 | Radford, Va. (Dedmon Center) | Winthrop 65, Radford 60 | Box score |
| 01-21-06 | Lynchburg, Va. (Vines Center) | Liberty 56, Winthrop 44 | Box score |
| 1-18-06 | Winthrop Coliseum, Rock Hill, SC | WINTHROP 54, UNCA 51 | Box score |
| 01-14-06 | Birmingham, Ala. (Bill Battle Coliseum) | Winthrop 69, Birmingham-Southern 59 | Box score |
| 1-09-06 | Winthrop Coliseum, Rock Hill, SC | WINTHROP 60, TSU 55 | Box score |
| 1-07-06 | Winthrop Coliseum, Rock Hill, SC | WINTHROP 67, LONGWOOD 58 | Box score |
| 1-03-06 | Winthrop Coliseum, Rock Hill, SC | WINTHROP 56, WOF 44 | Box score |
| 12/30/05 | Clarksville, Tenn. (Dave Aaron Arena) | Austin Peay 79, Winthrop 64 | Box score |
| 12/23/05 | Fort Wayne, IN (Gates Sports Center) | Winthrop 60, IPFW 44 | Box score |
| 12/20/05 | Clemson, SC (Littlejohn Coliseum) | Clemson Tigers 52, WINTHROP 51 | Box score |
| 12-11-05 | Winthrop Coliseum, Rock Hill, SC | WINTHROP 66, NSU 42 | Box score |
| 12-05-05 | Halton Arena; Charlotte, N.C. | Charlotte 59, WINTHROP 57 | Box score |
| 12-03-05 | Winthrop Coliseum, Rock Hill, SC | WINTHROP 73, LIV 56 | Box score |
| 11/29/05 | Buies Creek, N.C. | Campbell 79, Winthrop 64 | Box score |
| 11-23-05 | Winthrop Coliseum, Rock Hill, SC | ASU 64, WINTHROP 47 | Box score |
| 11/20/05 | Colonial Center (Columbia, S.C.) | South Carolina 73, Winthrop 42 | Box score |
| 11-18-05 | Winthrop Coliseum, Rock Hill, SC | UNF 73, WINTHROP 48 | Box score |