| Date | Location | Result | |
| 03/08/05 | Lynchburg, Va. (Vines Center) | #1 seed Liberty 83, #8 seed Winthrop 36 | Box score |
| 03-05-05 | High Point, N.C. (Millis Center) | High Point 77, Winthrop 50 | Box score |
| 02/28/05 | Lynchburg, Va. (Vines Center) | Liberty 79, Winthrop 26 | Box score |
| 2-26-05 | Winthrop Coliseum, Rock Hill, SC | Radford 88, Winthrop 50 | Box score |
| 02/23/05 | Asheville, N.C./ Justice Center | UNC Asheville 54, Winthrop 48 | Box score |
| 2-19-05 | Winthrop Coliseum, Rock Hill, SC | Birmingham-Southern 58, Winthrop 45 | Box score |
| 2-15-05 | Winthrop Coliseum, Rock Hill, SC | Charleston Southern 54, Winthrop 42 | Box score |
| 02-12-05 | Kimbel Arena, Conway, S.C. | Coastal Carolina 53, Winthrop 45 | Box score |
| 2- 9-05 | Winthrop Coliseum, Rock Hill, SC | LU 74, Winthrop 50 | Box score |
| 2/5/05 | Radford, Va. Dedmon Center | Radford 60, Winthrop 44 | Box score |
| 01-29-05 | Birmingham, Ala. (Bill Battle Coliseum) | Birmingham-Southern 69, Winthrop 46 | Box score |
| 1/25/05 | Charleston, S.C. | Charleston Southern 59, WINTHROP 43 | Box score |
| 1-22-05 | Winthrop Coliseum, Rock Hill, SC | COASTAL 52, Winthrop 46 | Box score |
| 1-18-05 | Winthrop Coliseum, Rock Hill, SC | UNCA 52, Winthrop 33 | Box score |
| 1-15-05 | Winthrop Coliseum, Rock Hill, SC | HPU 55, Winthrop 52 | Box score |
| 01/06/05 | Chapel Hill, N.C., Carmichael Auditorium | North Carolina 79, Winthrop 29 | Box score |
| 1-03-05 | Winthrop Coliseum, Rock Hill, SC | APSU 49, Winthrop 46 | Box score |
| 12-30-04 | Winthrop Coliseum, Rock Hill, SC | Alabama A&M 55, Winthrop 44 | Box score |
| 12-21-04 | Nashville, Tennessee (Gentry Center) | Winthrop 59, Tennessee State 50 | Box score |
| 12/19/04 | Cookeville, Tenn. | Tennessee Tech University 73, Winthrop University 54 | Box score |
| 12-11-04 | Winthrop Coliseum, Rock Hill, SC | Winthrop 63, Campbell 58 | Box score |
| 12/5/04 | Pizzitola Sports Center | BGSU 74, WINTHROP 52 | Box score |
| 12/4/04 | Pizzitola Sports Center | Brown University 69, WINTHROP 61 | Box score |
| 11-30-04 | Winthrop Coliseum, Rock Hill, SC | UMESW 62, Winthrop 55 | Box score |
| 11/27/04 | Fleming Gym; Greensboro, NC | South Carolina State 56, Winthrop 51 | Box score |
| 11/26/04 | Greensboro, NC (Fleming Gym | UNCG 62, WINTHROP 52 | Box score |
| 11/20/04 | Farmville, Va. | Fairleigh Dickinson 66, Winthrop 42 | Box score |
| 11/19/04 | Farmville, Va. | Longwood University 76, Winthrop 45 | Box score |