| Date | Location | Result | |
| 03/06/22 | Charlotte, NC | Longwood 79, Winthrop 58 | Box score |
| 03/05/22 | Charlotte, NC | Winthrop 76, Gardner-Webb 67 | Box score |
| 03/04/22 | Charlotte, NC | Winthrop 68, High Point 51 | Box score |
| 02/26/22 | Rock Hill, SC | Winthrop 92, Charleston So. 86 | Box score |
| 02/24/22 | Rock Hill, SC | Winthrop 89, USC Upstate 59 | Box score |
| 02/19/22 | Asheville, NC | Winthrop 84, UNC Asheville 79 | Box score |
| 02/16/22 | Boiling Springs, NC | Winthrop 81, Gardner-Webb 70 | Box score |
| 02/12/22 | Rock Hill, SC | Winthrop 65, Presbyterian 61 | Box score |
| 02/09/22 | Rock Hill, SC | Winthrop 58, Radford 48 | Box score |
| 02/05/22 | Hampton, VA | Winthrop 69, Hampton 57 | Box score |
| 02/03/22 | Rock Hill, SC | Winthrop 64, N.C. A&T 54 | Box score |
| 01/29/22 | Farmville, VA | Longwood 92, Winthrop 88 | Box score |
| 01/26/22 | Spartanburg, SC | Winthrop 95, USC Upstate 91 (OT) | Box score |
| 01/24/22 | High Point, NC | High Point 65, Winthrop 56 | Box score |
| 01/22/22 | Rock Hill, SC | Winthrop 64, Gardner-Webb 62 | Box score |
| 01/20/22 | Clinton, SC | Winthrop 60, Presbyterian 58 | Box score |
| 01/15/22 | North Charleston, SC | Winthrop 70, Charleston So. 65 | Box score |
| 01/13/22 | Rock Hill, SC | Winthrop 86, UNC Asheville 80 (OT) | Box score |
| 01/10/22 | Rock Hill, SC | Winthrop 74, Campbell 72 | Box score |
| 12/31/21 | Rock Hill, SC | Winthrop 78, Converse 40 | Box score |
| 12/21/21 | Starkville, MS | Mississippi St. 84, Winthrop 63 | Box score |
| 12/15/21 | Elon, NC | Elon 63, Winthrop 61 | Box score |
| 12/11/21 | Rock Hill, SC | Winthrop 83, Carver 52 | Box score |
| 12/07/21 | Rock Hill, SC | Winthrop 85, Furman 80 | Box score |
| 12/04/21 | Conway, SC | Coastal Carolina 74, Winthrop 64 | Box score |
| 12/01/21 | Rock Hill, SC | Winthrop 82, Hartford 75 | Box score |
| 11/27/21 | Seattle, WA | Winthrop 82, Washington 74 | Box score |
| 11/22/21 | Pullman, WA | Washington St. 92, Winthrop 86 | Box score |
| 11/20/21 | Nashville, TN | Vanderbilt 77, Winthrop 63 | Box score |
| 11/16/21 | Murfreesboro, TN | Middle Tenn. 76, Winthrop 65 | Box score |
| 11/13/21 | Rock Hill, SC | Winthrop 88, Mercer 85 (OT) | Box score |
| 11/09/21 | Rock Hill, SC | Winthrop 110, Mary Baldwin 78 | Box score |